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In 2017, French researchers from the Institut National de la Recherche Agronomique (INRAE) were among the first to examine the effects of E171 nanoparticles on the body. They fed rats a dose of 10mg of E171 per kilogram of body weight per day, which was similar to human exposure in food. The research, which was published in Scientific Reports, showed that E171 was able to traverse the intestinal barrier, pass into the bloodstream, and reach other areas of the body in rats. Researchers also found a link between immune system disorders and the absorption of titanium dioxide nanoparticles. 

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In conclusion, the top 20 titanium dioxide manufacturers represent a cross-section of innovation, reliability, and commitment to quality. These companies are instrumental in driving the development of new products and applications while ensuring the consistent supply of this crucial material. As the demand for titanium dioxide continues to grow across various industries, these manufacturers will undoubtedly play a significant role in shaping the future of this versatile compound.

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