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In conclusion, China's role in the global titanium dioxide industry, identified by its CAS number 13463-67-7, is both influential and complex. While the country's abundant resources and manufacturing prowess have solidified its position as a major supplier, it faces the ongoing challenge of balancing economic growth with environmental sustainability. As the world shifts towards cleaner practices, China's journey in the titanium dioxide sector will continue to shape the industry's future direction.

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Mexican researchers sought to evaluate the effects of E171 across a span of conditions in mice, including its influence on behavior, along with the effects on the colon and liver. The research, published in 2020 in the journal Food and Chemical Toxicology, showed that E171 promoted anxiety and induced adenomas, or noncancerous tumors, in the colon. They also found that E171 heightened goblet cells hypertrophy and hyperplasia, which is typically seen in asthma patients and triggered by smoking or external pollutants and toxins. They also noted mucins overexpression in the mice, which can be linked to cancer cell formation. 

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