china r996 tio2

Lithopone, a blend of zinc sulfide and barium sulfate, is prized for its opaque nature and ability to confer high brilliance and stability to colors. It has traditionally been used in a wide array of applications, from paints and plastics to rubber and printing inks. However, with the advent of new environmental regulations and the push for safer, non-toxic materials, there has been a renewed interest in lithopone production techniques that minimize hazardous waste and maximize efficiency.

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Mexican researchers sought to evaluate the effects of E171 across a span of conditions in mice, including its influence on behavior, along with the effects on the colon and liver. The research, published in 2020 in the journal Food and Chemical Toxicology, showed that E171 promoted anxiety and induced adenomas, or noncancerous tumors, in the colon. They also found that E171 heightened goblet cells hypertrophy and hyperplasia, which is typically seen in asthma patients and triggered by smoking or external pollutants and toxins. They also noted mucins overexpression in the mice, which can be linked to cancer cell formation. 

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