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In recent years, manufacturers have been focusing on improving the efficiency of these processes through technological advancements. For instance, the adoption of nanotechnology has enabled the production of TIO2 nanoparticles, enhancing the performance of end-products while reducing the overall amount needed. Additionally, efforts are being made to develop eco-friendly manufacturing methods, such as recycling TIO2 waste and utilizing renewable energy sources Additionally, efforts are being made to develop eco-friendly manufacturing methods, such as recycling TIO2 waste and utilizing renewable energy sources Additionally, efforts are being made to develop eco-friendly manufacturing methods, such as recycling TIO2 waste and utilizing renewable energy sources Additionally, efforts are being made to develop eco-friendly manufacturing methods, such as recycling TIO2 waste and utilizing renewable energy sourcestio2 procurement manufacturers.

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A few non-dietary studies have reported adverse effects in the gastrointestinal tract of laboratory animals given food-grade TiO2. However, these same effects were not seen when the same or higher doses of food-grade TiO2 were administered in the animals' diet. Dietary studies best reflect how humans are exposed to TiO2 from food. Thus, the Food Directorate placed the most emphasis on the results of these studies in the state of the science report.

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