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No acute effects of nano-sized TiO2 were observed in Danio rerio (zebrafish) embryos. Exposure of rainbow trout to TiO2 NPs triggered lipid peroxidation, influence on the respiratory tract, disturbance in the metabolism of Cu and Zn, induction of intestinal erosion  and accumulation in kidney tissue. Linhua et al. exposed juvenile carp to 100 and 200 mg/ml of particles and TiO2 observed no mortality. However, the fish suffered from oxidative stress and pathological changes in gill and liver. In the infaunal species Arenicola marina, exposure to TiO2 NPs in sediment caused sub-lethal effects including decrease in casting rate and increase in cellular and DNA damage. Aggregated particles were visible in the lumen of the gut, but no uptake through the gut or the skin was observed.

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Overall, the R2196 Titanium Dioxide Factory is a prime example of a modern, sustainable, and customer-focused manufacturing facility. Through its dedication to quality, sustainability, innovation, and customer satisfaction, the factory continues to be a driving force in the titanium dioxide industry. With its state-of-the-art technology, skilled workforce, and unwavering commitment to excellence, the R2196 Titanium Dioxide Factory is poised to remain a key player in the global market for years to come.

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