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While IARC listed titanium dioxide as “possibly carcinogenic to humans,” they also add that “there is inadequate evidence in humans for the carcinogenicity of titanium dioxide.” Of the four human studies that they reviewed, only one showed a potential risk for occupational workers inhaling titanium dioxide particles and lung cancer, while the other three showed no risk for cancer at all. And it’s key to note that IARC did not assess the effects of titanium dioxide found in foods.

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In addition to its use as a pigment, titanium dioxide has emerged as a key player in photocatalysis and solar energy conversion due to its semiconducting properties. It can split water molecules or decompose organic compounds when exposed to light, which is a promising feature for environmental clean-up operations and renewable energy initiatives It can split water molecules or decompose organic compounds when exposed to light, which is a promising feature for environmental clean-up operations and renewable energy initiatives It can split water molecules or decompose organic compounds when exposed to light, which is a promising feature for environmental clean-up operations and renewable energy initiatives It can split water molecules or decompose organic compounds when exposed to light, which is a promising feature for environmental clean-up operations and renewable energy initiativesr 5566 titanium dioxide. Furthermore, when titanium dioxide nanoparticles are incorporated into cement or concrete, they can endow self-cleaning properties to architectural surfaces by promoting the breakdown of pollutants like nitrogen oxides under UV light.

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In a study published in the journal Toxicology, researchers examined the effects of exposing human colon cancer cell line (HTC116) titanium dioxide food additives in vitro. “In the absence of cytotoxicity, E171 was accumulated in the cells after 24 hours of exposure, increasing granularity and reactive oxygen species, inducing alterations in the molecular pattern of nucleic acids and lipids, and causing nuclei enlargement, DNA damage and tubulin depolymerization,” the scientists wrote. Researchers removed the additive from the culture, then examined the results 48 hours later. They found, “The removal of E171 was unable to revert the alterations found after 24 h of exposure in colon cells. In conclusion, exposure to E171 causes alterations that cannot be reverted after 48 h if E171 is removed from colon cells.”

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