The ingredient in question? Titanium dioxide.

While the FDA maintains that the regulated use of titanium dioxide is safe, the European Food Safety Authority and some other experts warn of potential, serious health risks.

A review published in 2022 in the journal NanoImpact evaluated the latest research related to genotoxic effects of titanium dioxide through in vivo studies and in vitro cell tests. Researchers summarized the results by stating TiO2 nanoparticles “could induce genotoxicity prior to cytotoxicity,” and “are likely to be genotoxic to humans.”