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For a mini-review published in the journal Particle and Fibre Technology in 2021, scientists wanted to evaluate whether Ti02 particles contributed to the development and/or exacerbation of irritable bowel disease, and whether they altered the four elements of intestinal barrier function: the intestinal microbiota, the immune system, the mucus layer, and the epithelium. The breakdown of these four elements can contribute to autoimmune, neurological, inflammatory, infectious, and metabolic diseases. Following their review, the researchers concluded: “Data indicate that TiO2 is able to alter the four compartments of IBF and to induce a low-grade intestinal inflammation associated or not with pre-neoplastic lesions.”
Infrared analysis showed that the characteristics bands for the bare nanoparticles are still exhibited in the vitamins@P25TiO2NPs spectra, such as a wide peak in 450–1028 cm−1 related to the stretching vibration of Ti-O-Ti and other peaks in 1630 cm−1 and 3400 cm−1, which represent the surface OH groups stretching. The IR spectrum of vitaminB2@P25TiO2NPs showed signs of binding between compounds. The OH bending peak (1634 cm−1) corresponding to bare nanoparticles disappeared, and the NH2 bending band characteristic of vitamin B2 appeared (1650 cm−1). The IR spectrum of vitaminC@P25TiO2NPs also showed signs of successful functionalization. Bands at 1075 cm−1; 1120 cm−1; 1141 cm−1 were observed, which are originated by C
O-C vibrations present in the vitamin C. The intense band at 1672 cm−1 is attributed to the C = O stretching in the lactone ring while the peak at 1026 cm−1 is ascribed to the stretching vibration Ti-O-C. Wide bands at 3880–3600 cm−1 are related to stretching vibration OH groups, but those disappear in the modified nanoparticles spectrum. These observations confirm the interactions between the P25TiO2NPs and the vitamins [35].
