titanium dioxide is prepared from factory

In a 2016 study published in Scientifica (Cairo), Egyptian researchers examined the effects of titanium dioxide nanoparticles on the organs of mice by orally administering the food additive daily, for five days. The results showed that the exposure produced “mild to moderate changes in the cytoarchitecture of brain tissue in a time dependent manner.” Furthermore, “Comet assay revealed the apoptotic DNA fragmentation, while PCR-SSCP pattern and direct sequencing showed point mutation of Presenilin 1 gene at exon 5, gene linked to inherited forms of Alzheimer’s disease.” The researchers wrote: “From these findings, “the present study concluded that TiO2NPs is genotoxic and mutagenic to brain tissue which in turn might lead to Alzheimer’s disease incidence.”

...

Calcium carbonate is a versatile mineral that is used in a variety of industries, including paper, paints, plastics, and pharmaceuticals. It is most commonly used as a filler and pigment in products such as paper, paints, plastics, and rubber. In the paper industry, calcium carbonate is used as a filler to increase the brightness and opacity of paper, while in the paint industry, it is used as a pigment to provide color and durability.

...